Mytilene is the capital and main port of Lesvos Island in the northeastern Aegean Sea. It is located on the southeastern coast of the island and serves as the main administrative, economic, and cultural center.

The city has a long history dating back to antiquity and is known for its neoclassical buildings, the Castle of Mytilene, and its vibrant cultural life. Its port connects Lesvos with mainland Greece and nearby regions.

Today, Mytilene is a lively modern city with a university, services, commercial activity, and significant tourism, especially during the summer months.